In the mid-21st century, crop blights and dust storms threaten humanity's survival. Joseph Cooper, a widowed former NASA pilot, runs a farm with his father-in-law, son Tom, and daughter Murphy. Living in a post-truth society, Cooper is reprimanded for telling Murphy that the Apollo missions were not fake, and encourages her to carefully observe and record what she sees. They discover that dust patterns, which Murphy first attributes to a ghost, result from gravity variations, and translate into geographic coordinates. These lead them to a secret NASA facility headed by Cooper's former supervisor, Professor John Brand, who explains that 48 years earlier a wormhole appeared near Saturn, opening a path to a distant galaxy with twelve potentially habitable planets located near a black hole named Gargantua. Volunteers had previously traveled through the wormhole to evaluate the planets, with Miller, Edmunds, and Mann reporting back desirable results. Plan A attempts to develop a new gravitational propulsion theory, allowing a mass exodus from Earth. Plan B is a conventional launch of the Endurance spacecraft with 5,000 frozen embryos to colonize a habitable planet and ensure humanity's survival. Cooper is recruited to pilot the Endurance and accepts against Murphy's wishes. When she refuses to see him off, he leaves her his wristwatch to compare their relative time when he returns.