Sherlock Holmes: A Game of Shadows

In 1891, Irene Adler delivers a package to Dr. Hoffmanstahl, payment for a letter he was to deliver. Hoffmanstahl opens the package, triggering a bomb that is prevented from detonating by Sherlock Holmes. Holmes takes the letter while Adler and Hoffmanstahl escape. Holmes later finds Hoffmanstahl assassinated. Adler meets with Professor Moriarty to explain the events, but Moriarty, deeming her compromised, poisons and kills her.