In the late spring of 1959, the peaceful, all-white neighborhood of Suburbicon is shaken by the arrival of the African-American Mayers family.

Gardner Lodge, a seemingly mild-mannered family man, lives in Suburbicon with his paraplegic wife, Rose, and their son, Nicky. One night when Rose's identical twin sister, Margaret, is staying over, two robbers, Sloan and Louis, break into his house, tie the whole family up, and knock them out with chloroform. Rose receives an overdose and never regains consciousness. After the funeral, Margaret moves in to help take care of Nicky and soon begins to transform herself into Rose, dyeing her hair blonde and having sex with Gardner.