Amid the political protests of the Saffron Revolution in Burma, ruthless SPDC officer Major Pa Tee Tint leads Burmese junta army forces in pillaging small villages in a campaign of fear. His soldiers sadistically slaughter innocents, abduct teenage boys to be drafted into his army and hold women hostage to be raped as sex slaves. Meanwhile, 20 years after the events in Afghanistan, Vietnam War veteran John Rambo is still living in Thailand, making a meager living as a snake catcher and by providing boat rides. A missionary doctor from Colorado named Michael Burnett hires Rambo to ferry his group up the Salween River into Burma on a humanitarian mission to provide medical aid to a village inhabited by the Karen people. Rambo initially refuses, then agrees when asked by Michael's fiancée Sarah Miller.