Who Framed Roger Rabbit

In 1947 Los Angeles, "toons" act in theatrical cartoon shorts as with live-action films; they regularly interact with real people and animals and reside in Toontown. Private detective Eddie Valiant and his brother, Teddy, once worked closely with the toons on several famous cases, but after Teddy was killed by a toon, Eddie lapsed into alcoholism and vowed never to work for toons again.

R.K. Maroon, head of Maroon Cartoon Studios, is concerned about the recent poor performances of one of his biggest stars, Roger Rabbit. Maroon hires Valiant to investigate rumors about Roger's voluptuous toon wife Jessica being romantically involved with businessman and gadget inventor, Marvin Acme, owner of both Acme Corporation and Toontown. After watching Jessica perform at the underground Ink and Paint Club, Valiant secretly photographs her and Acme playing patty-cake in her dressing room, which he shows to Roger. Maroon suggests to Roger that he should leave Jessica, but a drunken Roger refuses and flees. Read more on Wikipedia.