The long-running, critically acclaimed, and incredibly beloved sitcom Frasier was produced because of the popularity of Kelsey Grammer's character, Dr. Frasier Crane, on Cheers. While the show was Frasier's in name, however, many fans would tell you that it truly belonged to the character of Dr. Niles Crane. Frasier's younger, much more paranoid and impossibly witty brother was played to absolute perfection by David Hyde Pierce.